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Article

Delineation of the role of the Mre11 complex in class switch recombination.

The Journal of biological chemistry - 16 Apr 2004

Lähdesmäki Aleksi, Taylor A Malcolm R, Chrzanowska Krystyna H, Pan-Hammarström Qiang

Abstract excerpt

Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID). The initial lesions in the switch (S) regions are processed and resolved, leading to a recombination of the t...

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Share to Acid Anhydride Hydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14747472
DOI: 10.1074/jbc.M312796200

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14747472-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Delineation of the role of the Mre11 complex in class switch recombination.PMID 14747472Read ↗

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Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.Semantic proximity Read ↗

Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombinationSemantic proximity Read ↗

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation.Semantic proximity Read ↗

Exonuclease function of human Mre11 promotes deletional nonhomologous end joining.Semantic proximity Read ↗

MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaksSemantic proximity Read ↗

Genetic Risk Variants for Class Switching Recombination Defects in Ataxia-Telangiectasia Patients.Semantic proximity Read ↗

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.Semantic proximity Read ↗

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