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Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination

3 Mar 2014

Abstract excerpt

Activation-induced deaminase (AID) triggers antibody class switch recombination (CSR) in B cells by initiating DNA double strand breaks that are repaired by nonhomologous end-joining pathways. A role for AID at the repair step is unclear. We show that specific inactivation of the C-terminal AID domain encoded by exon 5 (E5) allows very efficient deamination of the AID target regions but greatly impacts the...

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PMID: 24591601
DOI: 10.1073/pnas.1320486111

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