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Article

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells.

The Journal of experimental medicine - 17 Jan 2005

Pan-Hammarström Qiang, Jones Anne-Marie, Lähdesmäki Aleksi, Zhou Wei, Gatti Richard A, Hammarström Lennart, Gennery Andrew R, Ehrenstein Michael R

Abstract excerpt

Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID). The initial lesions in the switch (S) regions are subsequently processed and resolved, leading to recombination of the two targeted S regions. The mechanisms by which repair and ligation of the broken DNA ends occurs is still...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunoglobulin A

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Share to Recombination, Genetic

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Source

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Identifiers

PMID: 15657289
DOI: 10.1084/jem.20040772
PMCID: PMC2212791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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