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Article

Roles for NBS1 in alternative nonhomologous end-joining of V(D)J recombination intermediates.

Molecular cell - 10 Apr 2009

Deriano Ludovic, Stracker Travis H, Baker Annalee, Petrini John H J, Roth David B

Abstract excerpt

Recent work has highlighted the importance of alternative, error-prone mechanisms for joining DNA double-strand breaks (DSBs) in mammalian cells. These noncanonical, nonhomologous end-joining (NHEJ) pathways threaten genomic stability but remain poorly characterized. The RAG postcleavage complex normally prevents V(D)J recombination-associated DSBs from accessing alternative NHEJ. Because the MRE11/RAD50/NBS1...

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Share to Acid Anhydride Hydrolases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

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Share to MRE11 Homologue Protein

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Source

Open in PubMed Open full text

Identifiers

PMID: 19362533
DOI: 10.1016/j.molcel.2009.03.009
PMCID: PMC2704125

Genes

MRE11
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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