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Article

Disparate roles of ATR and ATM in immunoglobulin class switch recombination and somatic hypermutation.

The Journal of experimental medicine - 23 Jan 2006

Pan-Hammarström Qiang, Lähdesmäki Aleksi, Zhao Yaofeng, Du Likun, Zhao Zhihui, Wen Sicheng, Ruiz-Perez Victor L, Dunn-Walters Deborah K, Goodship Judith A, Hammarström Lennart

Abstract excerpt

Class switch recombination (CSR) and somatic hypermutation (SHM) are mechanistically related processes initiated by activation-induced cytidine deaminase. Here, we have studied the role of ataxia telangiectasia and Rad3-related protein (ATR) in CSR by analyzing the recombinational junctions, resulting from in vivo switching, in cells from patients with mutations in the ATR gene. The proportion of cells that have...

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Share to Ataxia Telangiectasia Mutated Proteins
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Class Switching

Share to Immunoglobulin mu-Chains

Share to Immunoglobulin Variable Region

Share to Protein Serine-Threonine Kinases

Share to Somatic Hypermutation, Immunoglobulin

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Source

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Identifiers

PMID: 16390936
DOI: 10.1084/jem.20050595
PMCID: PMC2118080

Genes

ATR
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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