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Article

Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

The Journal of biological chemistry - 14 Nov 2003

Lee Ji-Hoon, Ghirlando Rodolfo, Bhaskara Venugopal, Hoffmeyer Michaela R, Gu Jian, Paull Tanya T

Abstract excerpt

The Mre11/Rad50 complex is a critical component of the cellular response to DNA double-strand breaks, in organisms ranging from archaebacteria to humans. In mammalian cells, Mre11/Rad50 (M/R) associates with a third component, Nbs1, that regulates its activities and is targeted by signaling pathways that initiate DNA damage-induced checkpoint responses. Mutations in the genes that encode Nbs1 and Mre11 are...

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Identifiers

PMID: 12966088
DOI: 10.1074/jbc.M308705200

Genes

MRE11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.PMID 12966088Read ↗

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

The Mammalian Mre11-Rad50-Nbs1 Protein Complex: Integration of Functions in the Cellular DNA–Damage ResponseSemantic proximity Read ↗

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.Semantic proximity Read ↗

ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.Semantic proximity Read ↗

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairSemantic proximity Read ↗

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts.Semantic proximity Read ↗

Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms.Semantic proximity Read ↗

Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response.Semantic proximity Read ↗

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and RepairSemantic proximity Read ↗

The MRN complex in double-strand break repair and telomere maintenance.Semantic proximity Read ↗

Mre11 assembles linear DNA fragments into DNA damage signaling complexes.Semantic proximity Read ↗

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