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Article

Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination.

The Journal of experimental medicine - 22 Dec 2008

Du Likun, van der Burg Mirjam, Popov Sergey W, Kotnis Ashwin, van Dongen Jacques J M, Gennery Andrew R, Pan-Hammarström Qiang

Abstract excerpt

DNA double-strand breaks (DSBs) introduced in the switch (S) regions are intermediates during immunoglobulin class switch recombination (CSR). These breaks are subsequently recognized, processed, and joined, leading to recombination of the two S regions. Nonhomologous end-joining (NHEJ) is believed to be the principle mechanism involved in DSB repair during CSR. One important component in NHEJ, Artemis, has...

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Share to B-Lymphocytes
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Endonucleases

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Share to Recombination, Genetic

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Source

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Identifiers

PMID: 19075292
DOI: 10.1084/jem.20081915
PMCID: PMC2605234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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