Article
Syntaxin-6 SNARE involvement in secretory and endocytic pathways of cultured pancreatic beta-cells.
Molecular biology of the cell - 1 Apr 2004
Kuliawat Regina, Kalinina Elena, Bock Jason, Fricker Lloyd, McGraw Timothy E, Kim Se Ryoung, Zhong Jiayu, Scheller Richard, Arvan Peter
Abstract excerpt
In pancreatic beta-cells, the syntaxin 6 (Syn6) soluble N-ethylmaleimide-sensitive factor attachment protein receptor is distributed in the trans-Golgi network (TGN) (with spillover into immature secretory granules) and endosomes. A possible Syn6 requirement has been suggested in secretory granule biogenesis, but the role of Syn6 in live regulated secretory cells remains unexplored. We have created an...
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