Article
Proteolytic function of GPI-anchored plasma membrane protease Yps1p in the yeast vacuole and Golgi.
Traffic (Copenhagen, Denmark) - 1 Dec 2001
Sievi E, Suntio T, Makarow M
Abstract excerpt
Yps1p is a member of the GPI-anchored aspartic proteases which reside at the plasma membrane of Saccharomyces cerevisiae. Here we show that in Delta erg6 cells, where a late biosynthetic step of the membrane lipid ergosterol is blocked, part of Yps1p was targeted to the vacuole. There it overtook proteolytic functions of the Pep4p protease, resulting in processing of pro-CPY to CPY in cells lacking the PEP4 gene....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.