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Article

Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects.

The Journal of biological chemistry - 9 Apr 2004

Petrich Brian G, Eloff Benjamin C, Lerner Deborah L, Kovacs Attila, Saffitz Jeffrey E, Rosenbaum David S, Wang Yibin

Abstract excerpt

The stress-activated protein kinase, c-Jun N-terminal kinase (JNK), has been implicated in the process of cardiac hypertrophy and apoptosis, yet the specific roles of JNK in heart failure are unclear. To determine the effects of JNK activation in intact heart, we established transgenic animals using a Cre/loxP-mediated gene switch approach to achieve targeted expression of an upstream activator, mitogen-activated...

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Identifiers

PMID: 14742426
DOI: 10.1074/jbc.M314142200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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