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Article

Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases.

The Journal of clinical investigation - 1 Aug 1999

Choukroun G, Hajjar R, Fry S, del Monte F, Haq S, Guerrero J L, Picard M, Rosenzweig A, Force T

Abstract excerpt

Cardiac hypertrophy often presages the development of heart failure. Numerous cytosolic signaling pathways have been implicated in the hypertrophic response in cardiomyocytes in culture, but their roles in the hypertrophic response to physiologically relevant stimuli in vivo is unclear. We previously reported that adenovirus-mediated gene transfer of SEK-1(KR), a dominant inhibitory mutant of the immediate...

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Identifiers

PMID: 10449431
DOI: 10.1172/JCI6350
PMCID: PMC408523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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