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Article

Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis

1 Oct 2004

Abstract excerpt

The Raf/MEK/extracellular signal-regulated kinase (ERK) signaling pathway regulates diverse cellular processes such as proliferation, differentiation, and apoptosis and is implicated as an important contributor to the pathogenesis of cardiac hypertrophy and heart failure.To examine the in vivo role of Raf-1 in the heart, we generated cardiac muscle-specific Raf-1-knockout (Raf CKO) mice with Cre-loxP-mediated...

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PMID: 15467832
DOI: 10.1172/jci20317

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