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Article

Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells.

Immunity - 1 Jan 2004

Matsuzaki Yumi, Kinjo Kentaro, Mulligan Richard C, Okano Hideyuki

Abstract excerpt

Single-cell transplantation analysis revealed that the cells that had the strongest dye efflux activity ("Tip"-SP cells) and had the phenotype CD34- c-Kit+ Sca-1+ Lin- (CD34- KSL cells) exhibited very strong proliferation and multilineage differentiation capacity. Ninety-six percent of the lethally irradiated mice that received a single "Tip"-SP CD34- KSL cell showed significant donor cell engraftment for long...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14738767
DOI: 10.1016/s1074-7613(03)00354-6

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