Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

doi:10.1084/jem.175.1.175

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Article

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

The Journal of experimental medicine - 1 Jan 1992

Uchida N, Weissman I L

Abstract excerpt

Hematopoietic stem cells (HSCs) are defined in mice by three activities: they must rescue lethally irradiated mice (radioprotection), they must self-renew, and they must restore all blood cell lineages permanently. We initially demonstrated that HSCs were contained in a rare (approximately 0.05%)...

Topics

Animals
Antigens
Antigens, Surface
Bone Marrow
Bone Marrow Cells
Bone Marrow Transplantation
Cell Separation
Flow Cytometry
Hematopoietic Stem Cells
Mice
Mice, Inbred C57BL
Phenotype
Thy-1 Antigens

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