Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

The Journal of experimental medicine - 1 Jan 1992

Uchida N, Weissman I L

Abstract excerpt

Hematopoietic stem cells (HSCs) are defined in mice by three activities: they must rescue lethally irradiated mice (radioprotection), they must self-renew, and they must restore all blood cell lineages permanently. We initially demonstrated that HSCs were contained in a rare (approximately 0.05%) subset of bone marrow cells with the following surface marker profile: Thy-1.1lo Lin- Sca-1+. These cells were capable...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Surface
Share to Bone Marrow
Share to Bone Marrow Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Flow Cytometry

Share to Hematopoietic Stem Cells

Share to Mice, Inbred C57BL

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 1346154
DOI: 10.1084/jem.175.1.175
PMCID: PMC2119064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.PMID 1346154Read ↗

The Biology of Hematopoietic Stem CellsSemantic proximity Read ↗

Robust levels of long-term multilineage reconstitution in the absence of stem cell self-replication in W/Wv mice transplanted with purified stem cells.Semantic proximity Read ↗

Dormant and self-renewing hematopoietic stem cells and their niches.Semantic proximity Read ↗

Clonal analysis of hematopoietic stem-cell differentiation in vivo.Semantic proximity Read ↗

Phenotypic and functional characterization of the hematopoietic stem cell.Semantic proximity Read ↗

Phenotypic and functional changes induced in hematopoietic stem/progenitor cells after gamma-ray radiation exposure.Semantic proximity Read ↗

A simplified method for enrichment of mouse hematopoietic stem cells.Semantic proximity Read ↗

Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil-treated murine marrow.Semantic proximity Read ↗

Identification of the minimum requirements for successful haematopoietic stem cell transplantation.Semantic proximity Read ↗

Phenotypic analysis and isolation of murine hematopoietic stem cells and lineage-committed progenitors.Semantic proximity Read ↗

Characterization of a population of cells in the bone marrow that phenotypically mimics hematopoietic stem cells: resting stem cells or mystery population?Semantic proximity Read ↗

Distinct B-cell lineage commitment distinguishes adult bone marrow hematopoietic stem cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.