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Article

HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo.

Blood - 1 Mar 2003

Kunisato Atsushi, Chiba Shigeru, Nakagami-Yamaguchi Etsuko, Kumano Keiki, Saito Toshiki, Masuda Shigeo, Yamaguchi Tomoyuki, Osawa Masatake, Kageyama Ryoichiro, Nakauchi Hiromitsu, Nishikawa Mitsuo, Hirai Hisamaru

Abstract excerpt

Mouse long-term hematopoietic reconstituting cells exist in the c-Kit+Sca-1+Lin- (KSL) cell population; among them, CD34(low/-) cells represent the most highly purified population of hematopoietic stem cells in the adult bone marrow. Here, we demonstrate that retrovirus-mediated transduction of CD34(low/-)c-Kit+Sca-1+Lin- (34-KSL) cells with the HES-1 gene, which encodes a basic helix-loop-helix transcription...

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Identifiers

PMID: 12406868
DOI: 10.1182/blood-2002-07-2051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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