Article
A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology.
PloS one - 1 Jan 2011
Ricarte Florante, Menjivar Rosa, Chhun Surya, Soreta Tattika, Oliveira Lisa, Hsueh Teli, Serranilla Maribeth, Gharakhanian Editte
Abstract excerpt
Vacuoles of yeast Saccharomyces cerevisiae are functionally analogous to mammalian lysosomes. Both are cellular organelles responsible for macromolecular degradation, ion/pH homeostasis, and stress survival. We hypothesized that undefined gene functions remain at post-endosomal stage of vacuolar events and performed a genome-wide screen directed at such functions at the late endosome and vacuole interface - ENV...
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