Candida albicans VMA3 is necessary for V-ATPase assembly and function and contributes to secretion and filamentation.

doi:10.1128/EC.00118-13

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Article

Candida albicans VMA3 is necessary for V-ATPase assembly and function and contributes to secretion and filamentation.

Eukaryotic cell - 1 Oct 2013

Rane Hallie S, Bernardo Stella M, Raines Summer M, Binder Jessica L, Parra Karlett J, Lee Samuel A

Abstract excerpt

The vacuolar membrane ATPase (V-ATPase) is a protein complex that utilizes ATP hydrolysis to drive protons from the cytosol into the vacuolar lumen, acidifying the vacuole and modulating several key cellular response systems in Saccharomyces cerevisiae. To study the contribution of V-ATPase to the biology and virulence attributes of the opportunistic fungal pathogen Candida albicans, we created a conditional...

Topics

Aspartic Acid Proteases
Candida albicans
Exocytosis
Fungal Proteins
Lipase
Mutation
Protein Multimerization
Vacuolar Proton-Translocating ATPases
Vacuoles
Virulence

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Identifiers

PMID: 23913543
DOI: 10.1128/EC.00118-13
PMCID: PMC3811332

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