Article
Dampened activity of ryanodine receptor channels in mutant skeletal muscle lacking TRIC-A.
The Journal of physiology - 15 Jul 2017
El-Ajouz Sam, Venturi Elisa, Witschas Katja, Beech Matthew, Wilson Abigail D, Lindsay Chris, Eberhardt David, O'Brien Fiona, Iida Tsunaki, Nishi Miyuki, Takeshima Hiroshi, Sitsapesan Rebecca
Abstract excerpt
KEY POINTS: The role of trimeric intracellular cation (TRIC) channels is not known, although evidence suggests they may regulate ryanodine receptors (RyR) via multiple mechanisms. We therefore investigated whether Tric-a gene knockout (KO) alters the single-channel function of skeletal RyR (RyR1). We find that RyR1 from Tric-a KO mice are more sensitive to inhibition by divalent cations, although they respond...
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