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Article

R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts.

Biophysical journal - 1 Sept 2007

He Huamei, Javadpour Maryam M, Latif Farhana, Tardiff Jil C, Ingwall Joanne S

Abstract excerpt

It is now known that the flexibility of the troponin T (TnT) tail determines thin filament conformation and hence cross-bridge cycling properties, expanding the classic structural role of TnT to a dynamic role regulating sarcomere function. Here, using transgenic mice bearing R-92W and R-92L missense mutations in cardiac TnT known to alter the flexibility of the TnT tropomyosin-binding domain, we found...

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Identifiers

PMID: 17526570
DOI: 10.1529/biophysj.107.107557
PMCID: PMC1948064

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R-92L and R-92W mutations in cardiac troponin T lead to distinct energetic phenotypes in intact mouse hearts.PMID 17526570Read ↗

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