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Article

High T cell epitope sharing between two HLA-B27 subtypes (B2705 and B2709) differentially associated to ankylosing spondylitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1999

García-Peydró M, Martí M, López de Castro J A

Abstract excerpt

HLA-B*2705 is strongly associated with ankylosing spondylitis (AS) and reactive arthritis. In contrast, B*2709 has been reported to be more weakly or not associated to AS. These two molecules differ by a single amino acid change: aspartic acid in B*2705 or histidine in B*2709 at position 116. In this study, we analyzed the degree of T cell epitope sharing between the two subtypes. Ten allospecific T cell clones...

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Share to Clone Cells
Share to Cytotoxicity Tests, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-B27 Antigen

Share to Peptides

Share to Point Mutation

Share to Spondylitis, Ankylosing

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 10438975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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