Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis.

doi:10.1002/eji.1830251133

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Article

Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis.

European journal of immunology - 1 Nov 1995

D'Amato M, Fiorillo M T, Carcassi C, Mathieu A, Zuccarelli A, Bitti P P, Tosi R, Sorrentino R

Abstract excerpt

Ankylosing spondylitis (AS) is an autoimmune disorder strongly associated with HLA-B27. A direct role of B27 molecules in the disease pathogenesis has been postulated, possibly by presenting to T cells an as-yet unidentified arthritogenic peptide that triggers the autoimmune response. There are n...

Topics

Alleles
Amino Acid Sequence
Base Sequence
Disease Susceptibility
HLA-B27 Antigen
Humans
Italy
Molecular Sequence Data
Spondylitis, Ankylosing

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