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Article

Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis.

European journal of immunology - 1 Nov 1995

D'Amato M, Fiorillo M T, Carcassi C, Mathieu A, Zuccarelli A, Bitti P P, Tosi R, Sorrentino R

Abstract excerpt

Ankylosing spondylitis (AS) is an autoimmune disorder strongly associated with HLA-B27. A direct role of B27 molecules in the disease pathogenesis has been postulated, possibly by presenting to T cells an as-yet unidentified arthritogenic peptide that triggers the autoimmune response. There are nine HLA-B27 alleles differing from each other at one or more amino acid positions. It is important, for the...

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Source

Identifiers

PMID: 7489765
DOI: 10.1002/eji.1830251133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis.PMID 7489765Read ↗

HLA-B27 Subtypes Differentially Associated with Disease Exhibit Subtle Structural AlterationsSemantic proximity Read ↗

Molecular mechanism of the susceptibility difference between HLA-B*27:02/04/05 and HLA-B*27:06/09 to ankylosing spondylitis: substitution analysis, MD simulation, QSAR modelling, and in vitro assay.Semantic proximity Read ↗

Dual, HLA-B27 Subtype-dependent Conformation of a Self-peptideSemantic proximity Read ↗

Two distinctive HLA haplotypes harbor the B27 alleles negatively or positively associated with ankylosing spondylitis in Sardinia: implications for disease pathogenesis.Semantic proximity Read ↗

Binding of peptides naturally presented by HLA-B27 to the differentially disease-associated B*2704 and B*2706 subtypes, and to mutants mimicking their polymorphism.Semantic proximity Read ↗

Susceptibility to ankylosing spondylitis is independent of the Bw4 and Bw6 epitopes of HLA-B27 alleles.Semantic proximity Read ↗

The Peptide Repertoires of HLA-B27 Subtypes Differentially Associated to Spondyloarthropathy (B*2704 and B*2706) Differ by Specific Changes at Three Anchor PositionsSemantic proximity Read ↗

Susceptibility to ankylosing spondylitis correlates with the C‐terminal residue of peptides presented by various HLA‐B27 subtypesSemantic proximity Read ↗

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High T cell epitope sharing between two HLA-B27 subtypes (B*2705 and B*2709) differentially associated to ankylosing spondylitis.Semantic proximity Read ↗

HLA‐B27 subtypes in Asian patients with ankylosing spondylitis Evidence for new associationsSemantic proximity Read ↗

Possible protective role of HLA-B*2706 for ankylosing spondylitis.Semantic proximity Read ↗

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