Article
Differences in the regulation of intracellular calcium in normal and neoplastic keratinocytes are not caused by ras gene mutations.
Cancer research - 15 Aug 1991
Kruszewski F H, Hennings H, Tucker R W, Yuspa S H
Abstract excerpt
The development of resistance to terminal differentiation is an early event in epidermal neoplasia. Altered differentiation can be detected in vitro since normal epidermal cells are induced to differentiate in medium with Ca2+ greater than 0.1 mM while neoplastic epidermal cells and keratinocytes transduced with a v-rasHa gene are resistant to Ca2+. In normal epidermal cells, the elevation of extracellular Ca2+...
Topics
- 9,10-Dimethyl-1,2-benzanthracene
- Animals
- Calcium
- Cell Line
- Fura-2
- Gene Expression
- Genes, ras
- Keratinocytes
- Kinetics
- Mice
- Mice, Inbred BALB C
- Mice, Inbred Strains