Article
Inositol trisphosphate levels in cells expressing wild-type and mutant polyomavirus middle T antigens: evidence for activation of phospholipase C via activation of pp60c-src.
Journal of virology - 1 Jan 1990
Gorga F R, Riney C E, Benjamin T L
Abstract excerpt
The transforming protein of polyomavirus, middle T (mT), forms a complex with two cellular enzymes: the protein tyrosine kinase pp60c-src and a phosphatidylinositol (PtdIns) 3-kinase. A mutant virus, Py1178T, encodes an mT protein which associates with and activates pp60c-src to the same extent a...
Topics
- Animals
- Antigens, Polyomavirus Transforming
- Cell Line
- Cell Transformation, Viral
- Cells, Cultured
- Enzyme Activation
- Inositol
- Inositol 1,4,5-Trisphosphate
- Kinetics
- Mice
- Mutation
- Oncogene Protein pp60(v-src)