Article
A subset of Sjögren's syndrome associates with the TCRBV13S2 locus but not the TCRBV2S1 locus.
Human immunology - 1 Apr 1995
Kay R A, Hutchings C J, Ollier W E
Abstract excerpt
HGPSS associates with the TCRBV6S7 locus within the TCR beta-chain gene complex. However, V beta 6.7 T cells, encoded by this locus, have never been implicated in the salivary gland destruction that characterizes primary Sjögren's syndrome. Both V beta 13 and V beta 2 T cells have been implicated in glandular destruction. We therefore analyzed the association of HGPSS with both TCRBV2S1, the only TCRBV2 locus,...
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