Article
An abnormal T cell repertoire in hypergammaglobulinaemic primary Sjögren's syndrome.
Clinical and experimental immunology - 1 Aug 1991
Kay R A, Hay E M, Dyer P A, Dennett C, Green L M, Bernstein R M, Holt P J, Pumphrey R S, Boylston A W, Ollier W E
Abstract excerpt
T cell antigen specificity is determined by the products of the genes which encode the variable regions of their receptors. Of the T cell receptor (TCR) variable region gene products examined, only V beta 6.7a TCR-positive lymphocytes were reduced in primary Sjögren's syndrome patients with IgG1...
Topics
- Adult
- HLA Antigens
- HLA-DR Antigens
- Humans
- Hypergammaglobulinemia
- Immunoglobulin G
- Middle Aged
- Phenotype
- Receptors, Antigen, T-Cell
- Sjogren's Syndrome
- T-Lymphocytes