Article
An abnormal T cell repertoire in hypergammaglobulinaemic primary Sjögren's syndrome.
Clinical and experimental immunology - 1 Aug 1991
Kay R A, Hay E M, Dyer P A, Dennett C, Green L M, Bernstein R M, Holt P J, Pumphrey R S, Boylston A W, Ollier W E
Abstract excerpt
T cell antigen specificity is determined by the products of the genes which encode the variable regions of their receptors. Of the T cell receptor (TCR) variable region gene products examined, only V beta 6.7a TCR-positive lymphocytes were reduced in primary Sjögren's syndrome patients with IgG1 hypergammaglobulinaemia compared with an age-, sex- and HLA-matched control population. The levels of V beta 6.7a T...
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