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Article

The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.

Molecular and cellular biology - 1 Feb 2004

Imai Yoichi, Kurokawa Mineo, Yamaguchi Yuko, Izutsu Koji, Nitta Eriko, Mitani Kinuko, Satake Masanobu, Noda Tetsuo, Ito Yoshiaki, Hirai Hisamaru

Abstract excerpt

The AML1 (RUNX1) gene, one of the most frequent targets of translocations associated with human leukemias, encodes a DNA-binding protein that plays pivotal roles in myeloid differentiation through transcriptional regulation of various genes. Previously, we reported that AML1 is phosphorylated on...

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Identifiers

PMID: 14729951
DOI: 10.1128/MCB.24.3.1033-1043.2004
PMCID: PMC321417

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14729951-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

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The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.PMID 14729951Read ↗

Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association.Semantic proximity Read ↗

AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex.Semantic proximity Read ↗

Methylation of RUNX1 by PRMT1 abrogates SIN3A binding and potentiates its transcriptional activity.Semantic proximity Read ↗

Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.Semantic proximity Read ↗

NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.Semantic proximity Read ↗

Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells.Semantic proximity Read ↗

Subnuclear targeting of Runx1 is required for synergistic activation of the myeloid specific M-CSF receptor promoter by PU.1.Semantic proximity Read ↗

AML1/RUNX1 functions as a cytoplasmic attenuator of NF-κB signaling in the repression of myeloid tumors.Semantic proximity Read ↗

The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomesSemantic proximity Read ↗

The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.Semantic proximity Read ↗

AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression.Semantic proximity Read ↗

Identification and Characterization of Three New Components of the mSin3A Corepressor ComplexSemantic proximity Read ↗

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