Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex.

Molecular and cellular biology - 1 Oct 2006

Biggs Joseph R, Peterson Luke F, Zhang Youhong, Kraft Andrew S, Zhang Dong-Er

Abstract excerpt

AML1 (RUNX1) regulates hematopoiesis, angiogenesis, muscle function, and neurogenesis. Previous studies have shown that phosphorylation of AML1, particularly at serines 276 and 303, affects its transcriptional activation. Here, we report that phosphorylation of AML1 serines 276 and 303 can be blo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anaphase-Promoting Complex-Cyclosome
Share to Cadherins
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinases

Share to Cyclins

Share to Protein Subunits

Share to S-Phase Kinase-Associated Proteins

Share to Ubiquitin-Protein Ligase Complexes

Source

Open in PubMed Open full text

Identifiers

PMID: 17015473
DOI: 10.1128/MCB.00597-06
PMCID: PMC1636878

Genes

APC
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17015473-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex.PMID 17015473Read ↗

Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association.Semantic proximity Read ↗

The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.Semantic proximity Read ↗

Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.Semantic proximity Read ↗

AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.Semantic proximity Read ↗

AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression.Semantic proximity Read ↗

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent mannerSemantic proximity Read ↗

Phosphorylation of the Anaphase Promoting Complex activator CDH1/FZR regulates the transition from Meiosis I to Meiosis II in mouse male germ cellSemantic proximity Read ↗

Aurora kinase-induced phosphorylation excludes transcription factor RUNX from the chromatin to facilitate proper mitotic progression.Semantic proximity Read ↗

Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation.Semantic proximity Read ↗

O-GlcNAcylation Antagonizes Phosphorylation of CDH1 (CDC20 Homologue 1).Semantic proximity Read ↗

Multi-kinase phosphorylation of the APC/C activator Cdh1 revealed by mass spectrometry.Semantic proximity Read ↗

Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.