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Nuclear accumulation of SHIP1 mutants derived from AML patients leads to increased proliferation of leukemic cells.

Cellular signalling - 1 Sept 2018

Nalaskowski Marcus M, Ehm Patrick, Rehbach Christoph, Nelson Nina, Täger Maike, Modest Kathrin, Jücker Manfred

Abstract excerpt

The inositol 5-phosphatase SHIP1 acts as negative regulator of intracellular signaling in myeloid cells and is a tumor suppressor in myeloid leukemogenesis. After relocalization from the cytoplasm to the plasma membrane SHIP1 terminates PI3-kinase mediated signaling processes. Furthermore, SHIP1 is also found in distinct puncta in the cell nucleus and nuclear SHIP1 has a pro-proliferative function. Here we report...

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PMID: 29852247
DOI: 10.1016/j.cellsig.2018.05.006

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