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Article

Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association.

Molecular cancer research : MCR - 1 Jul 2005

Biggs Joseph R, Zhang Youhong, Peterson Luke F, Garcia Marileila, Zhang Dong-Er, Kraft Andrew S

Abstract excerpt

The acute myeloid leukemia 1 (AML1) transcription factors are key regulators of hematopoietic differentiation. Cellular AML1c protein is found in the nucleus and can be separated into two fractions, one soluble in buffers containing salt and nonionic detergent and the other insoluble and tightly...

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Source

Identifiers

PMID: 16046550
DOI: 10.1158/1541-7786.MCR-04-0184

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16046550-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Phosphorylation of AML1/RUNX1 regulates its degradation and nuclear matrix association.PMID 16046550Read ↗

The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.Semantic proximity Read ↗

AML1/RUNX1 phosphorylation by cyclin-dependent kinases regulates the degradation of AML1/RUNX1 by the anaphase-promoting complex.Semantic proximity Read ↗

The leukemogenic t(8;21) fusion protein AML1-ETO controls rRNA genes and associates with nucleolar-organizing regions at mitotic chromosomesSemantic proximity Read ↗

Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3.Semantic proximity Read ↗

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AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues.Semantic proximity Read ↗

AML1/RUNX1 increases during G1 to S cell cycle progression independent of cytokine-dependent phosphorylation and induces cyclin D3 gene expression.Semantic proximity Read ↗

Degradation of the tumor suppressor PML by Pin1 contributes to the cancer phenotype of breast cancer MDA-MB-231 cells.Semantic proximity Read ↗

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Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.Semantic proximity Read ↗

Cytoplasmic Mislocalization of p27Kip1 Protein Is Associated with Constitutive Phosphorylation of Akt or Protein Kinase B and Poor Prognosis in Acute Myelogenous LeukemiaSemantic proximity Read ↗

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