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Article

Neurons lacking iron regulatory protein-2 are highly resistant to the toxicity of hemoglobin.

Neurobiology of disease - 1 Aug 2008

Regan Raymond F, Chen Mai, Li Zhi, Zhang Xuefeng, Benvenisti-Zarom Luna, Chen-Roetling Jing

Abstract excerpt

The effect of iron regulatory protein-2 (IRP2) on ferritin expression and neuronal vulnerability to hemoglobin was assessed in primary cortical cell cultures prepared from wild-type and IRP2 knockout mice. Baseline levels of H and L-ferritin subunits were significantly increased in IRP2 knockout neurons and astrocytes. Hemoglobin was toxic to wild-type neurons in mixed neuron-astrocyte cultures, with an LC(50)...

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Source

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Identifiers

PMID: 18571425
DOI: 10.1016/j.nbd.2008.04.008
PMCID: PMC2537465

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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