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Article

The cytoplasmic peptide:N-glycanase (NGLY1) - Structure, expression and cellular functions.

Gene - 10 Feb 2016

Suzuki Tadashi, Huang Chengcheng, Fujihira Haruhiko

Abstract excerpt

NGLY1/Ngly1 is a cytosolic peptide:N-glycanase, i.e. de-N-glycosylating enzyme acting on N-glycoproteins in mammals, generating free, unconjugated N-glycans and deglycosylated peptides in which the N-glycosylated asparagine residues are converted to aspartates. This enzyme is known to be involved in the quality control system for the newly synthesized glycoproteins in the endoplasmic reticulum (ER). In this...

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Source

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Identifiers

PMID: 26611529
DOI: 10.1016/j.gene.2015.11.021
PMCID: PMC4691572

Genes

NGLY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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