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Article

Endo-β-N-acetylglucosaminidase forms N-GlcNAc protein aggregates during ER-associated degradation in Ngly1-defective cells.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2015

Huang Chengcheng, Harada Yoichiro, Hosomi Akira, Masahara-Negishi Yuki, Seino Junichi, Fujihira Haruhiko, Funakoshi Yoko, Suzuki Takehiro, Dohmae Naoshi, Suzuki Tadashi

Abstract excerpt

The cytoplasmic peptide:N-glycanase (PNGase; Ngly1 in mice) is a deglycosylating enzyme involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) process. The precise role of Ngly1 in the ERAD process, however, remains unclear in mammals. The findings reported herein, using mouse embryonic fibroblast (MEF) cells, that the ablation of Ngly1 causes dysregulation of the ERAD process. Interestingly,...

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Share to Acetylglucosamine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase

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Share to Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase

Source

Open in PubMed Open full text

Identifiers

PMID: 25605922
DOI: 10.1073/pnas.1414593112
PMCID: PMC4321286

Genes

NGLY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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