Article
Yeast GTB1 encodes a subunit of glucosidase II required for glycoprotein processing in the endoplasmic reticulum.
The Journal of biological chemistry - 10 Mar 2006
Wilkinson Barrie M, Purswani Jessica, Stirling Colin J
Abstract excerpt
Glucosidase II is essential for sequential removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the endoplasmic reticulum. The enzyme is a heterodimer whose alpha-subunit contains the glycosyl hydrolase active site. The function of the beta-subunit has yet to be defined, but mutations in the human gene have been linked to an autosomal dominant form of polycystic liver disease....
Topics
- Amino Acid Sequence
- Endoplasmic Reticulum
- Glycoproteins
- Humans
- Molecular Sequence Data
- Mutation
- Oligosaccharides
- Polysaccharides
- Protein Processing, Post-Translational
- Protein Subunits
- Saccharomyces cerevisiae Proteins
- Sequence Alignment
- alpha-Glucosidases