Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent inactivation of the <i>p73</i> gene by abnormal methylation or LOH in non‐Hodgkin's lymphomas

25 Sept 2002

Abstract excerpt

p73 is a candidate tumor suppressor and imprinted gene that shares significant homology with the p53 gene. It is located on 1p36, a region frequently deleted in neuroblastoma and other tumors. To investigate the pattern of inactivation of this gene in human lymphomas, we studied 59 tumors to identify abnormal methylation in exon 1 and loss of heterozygosity (LOH) at this locus. p73 was methylated in 13/50 (26%) B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Neuroblastoma Research and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12353228
DOI: 10.1002/ijc.10618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent inactivation of the <i>p73</i> gene by abnormal methylation or LOH in non‐Hodgkin's lymphomasPMID 12353228Read ↗

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.Semantic proximity Read ↗

Molecular alterations of p73 in human esophageal squamous cell carcinomas: loss of heterozygosity occurs frequently; loss of imprinting and elevation of p73 expression may be related to defective p53.Semantic proximity Read ↗

Loss of heterozygosity, allele silencing and decreased expression of p73 gene in breast cancers: prevalence of alterations in inflammatory breast cancers.Semantic proximity Read ↗

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers.Semantic proximity Read ↗

Genomic and allelic expression status of the p73 gene in human neuroblastoma.Semantic proximity Read ↗

Infrequent somatic mutations of the p73 gene in various human cancers.Semantic proximity Read ↗

Methylation of the p73 gene in gliomas.Semantic proximity Read ↗

Frequent allelic losses on the short arm of chromosome 1 and decreased expression of the p73 gene at 1p36.3 in squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36.33 in human lung cancers.Semantic proximity Read ↗

Some facts and thoughts: p73 as a tumor suppressor gene in the network of tumor suppressors.Semantic proximity Read ↗

P73 gene expression in ovarian cancer tissues and cell lines.Semantic proximity Read ↗

Targeted deletion of p73 in mice reveals its role in T cell development and lymphomagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.