Article
Immunoglobulin gene rearrangements and mutational status in argentinian patients with chronic lymphocytic leukemia.
Clinical lymphoma, myeloma & leukemia - 1 Aug 2013
Stanganelli Carmen, Travella Ana, Bezares Raimundo, Slavutsky Irma
Abstract excerpt
BACKGROUND: Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease. The mutational status of the immunoglobulin heavy chain variable (IGHV) region represents one of the best prognostic markers and defines 2 disease subgroups: mutated (M-CLL) and unmutated (UM-CLL), with different clinical course. MATERIALS AND METHODS: IGHV-D-J gene rearrangements and mutational status were analyzed in 73...
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