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Article

N-glycosylation is essential for vesicular targeting of synaptotagmin 1.

Neuron - 8 Jan 2004

Han Weiping, Rhee Jeong-Seop, Maximov Anton, Lao Ye, Mashimo Tomoyuki, Rosenmund Christian, Südhof Thomas C

Abstract excerpt

Synaptotagmins 1 and 7 are candidate Ca(2+) sensors for exocytosis localized to synaptic vesicles and plasma membranes, respectively. We now show that the N-terminal intraluminal sequence of synaptotagmin 1, when transplanted onto synaptotagmin 7, redirects synaptotagmin 7 from the plasma membrane to secretory vesicles. Conversely, mutation of the N-terminal N-glycosylation site of synaptotagmin 1 redirects...

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PMID: 14715137
DOI: 10.1016/s0896-6273(03)00820-1

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