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Article

Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP.

Nature - 20 Apr 2017

Wu Dick, Bacaj Taulant, Morishita Wade, Goswami Debanjan, Arendt Kristin L, Xu Wei, Chen Lu, Malenka Robert C, Südhof Thomas C

Abstract excerpt

Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory. During the induction of NMDA-receptor-dependent LTP, Ca2+ influx stimulates recruitment of synaptic AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, thereby strengthening synapses. How Ca2+ induces the recruitment of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28355182
DOI: 10.1038/nature21720
PMCID: PMC5734942

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