Article
Synaptotagmin mutants Y311N and K326/327A alter the calcium dependence of neurotransmission.
Molecular and cellular neurosciences - 1 Jul 2005
Borden Catherine R, Stevens Charles F, Sullivan Jane M, Zhu Yongling
Abstract excerpt
Synaptotagmin I, a calcium-binding synaptic vesicle protein, is thought to act as the calcium sensor for fast neurotransmission, but what synaptotagmin I does, upon binding calcium, to trigger exocytosis is still unknown. To begin to examine the role of synaptotagmin I's interactions with calcium-dependent binding partners, three mutant versions of synaptotagmin I reported to affect calcium-dependent...
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