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Article

Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7.

PloS one - 2 Sept 2010

Xue Mingshan, Craig Timothy K, Shin Ok-Ho, Li Liyi, Brautigam Chad A, Tomchick Diana R, Südhof Thomas C, Rosenmund Christian, Rizo Josep

Abstract excerpt

Synaptotagmins are known to mediate diverse forms of Ca2+-triggered exocytosis through their C2 domains, but the principles underlying functional differentiation among them are unclear. Synaptotagmin-1 functions as a Ca2+ sensor in neurotransmitter release at central nervous system synapses, but synaptotagmin-7 does not, and yet both isoforms act as Ca2+ sensors in chromaffin cells. To shed light into this...

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Identifiers

PMID: 20824061
DOI: 10.1371/journal.pone.0012544
PMCID: PMC2932738

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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