Article
Detection of the four sequence variations of MDR1 gene using TaqMan MGB probe based real-time PCR and haplotype analysis in healthy Japanese subjects.
Clinical biochemistry - 1 Oct 2003
Saito Katsuhiko, Miyake Sachie, Moriya Hiroyuki, Yamazaki Miyuki, Itoh Fumio, Imai Kohzoh, Kurosawa Nahoko, Owada Eiji, Miyamoto Atsushi
Abstract excerpt
OBJECTIVES: P-glycoprotein (P-gp) is significant from the viewpoint of pharmacokinetics/pharmacodynamics (PK/PD). MDR1 gene encodes P-gp and has a wide variety of SNPs. As the SNPs may be one of the factors that induce pharmacogenetic individual difference, haplotype analysis is necessary to evaluate the PK/PD. DESIGN AND METHODS: The SNPs of the detected MDR1 were -129T>C, 325G>A, 2677G>T/A, and 3435C>T. For the...
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