Article
A functional polymorphism of the micro-opioid receptor gene is associated with completed suicides.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2008
Hishimoto A, Cui H, Mouri K, Nushida H, Ueno Y, Maeda K, Shirakawa O
Abstract excerpt
A recent linkage study suggested that a putative locus for suicidal behavior independent of psychiatric disease phenotypes lies at 5' upstream of the micro-opioid receptor (OPRM1) gene. We explored an association between suicide and genetic variations of the OPRM1 using a case-control study of 183 completed suicides and 374 control subjects. We genotyped four single nucleotide polymorphisms (SNPs) including a...
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