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Article

Chk2 suppresses the oncogenic potential of DNA replication-associated DNA damage.

Molecular cell - 11 Jul 2008

Stracker Travis H, Couto Suzana S, Cordon-Cardo Carlos, Matos Tulio, Petrini John H J

Abstract excerpt

The Mre11 complex (Mre11, Rad50, and Nbs1) and Chk2 have been implicated in the DNA-damage response, an inducible process required for the suppression of malignancy. The Mre11 complex is predominantly required for repair and checkpoint activation in S phase, whereas Chk2 governs apoptosis. We examined the relationship between the Mre11 complex and Chk2 in the DNA-damage response via the establishment of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18614044
DOI: 10.1016/j.molcel.2008.04.028
PMCID: PMC2586815

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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