Article
Novel genetic variations and haplotypes of hepatocyte nuclear factor 4alpha (HNF4A) found in Japanese type II diabetic patients.
Drug metabolism and pharmacokinetics - 1 Aug 2006
Fukushima-Uesaka Hiromi, Saito Yoshiro, Maekawa Keiko, Saeki Mayumi, Kamatani Naoyuki, Kajio Hiroshi, Kuzuya Nobuaki, Yasuda Kazuki, Sawada Jun-Ichi
Abstract excerpt
Thirty-nine single nucleotide variations, including 16 novel ones, were found in the 5' promoter region, all of the exons and their surrounding introns of HNF4A in 74 Japanese type II diabetic patients. The following novel variations were identified (based on the amino acid numbering of splicing variant 2): -208G>C in the 5' promoter region; 1154C>T (A385V) and 1193T>C (M398T) in the coding exons; 1580G>A,...
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