Article
The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response.
FEBS letters - 20 Apr 2001
Lindemann M, Virchow S, Ramann F, Barsegian V, Kreuzfelder E, Siffert W, Müller N, Grosse-Wilde H
Abstract excerpt
The G protein beta3 subunit (GNB3) 825T allele is predictive of enhanced Gi protein activation. Studying the influence of C825T allele status on cellular in vitro immune responses towards recall antigens and interleukin-2 stimulation we observed a 2-4-fold, significantly increased proliferation in homozygous 825T (TT) vs. C825 allele (CC) carriers. Furthermore, lymphocyte chemotaxis and CD4(+) T cell counts of...
Topics
- Alleles
- Antigens
- Antigens, CD
- CD4 Lymphocyte Count
- Cell Division
- Chemotaxis
- Female
- Genetic Markers
- Genotype
- Heterotrimeric GTP-Binding Proteins
- Heterozygote
- Homozygote
- Humans
- Immunocompetence
- Immunophenotyping