Article
Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit.
Biochimica et biophysica acta - 15 Apr 2003
Rosskopf Dieter, Kielbik Marzena, Manthey Iris, Bilmen Gölpar, Eisenhardt Andreas, Siffert Winfried
Abstract excerpt
A polymorphism (C825T) in the gene of the G-protein Gbeta3 (GNB3) has been the subject of numerous studies which have shown that the 825T-allele is associated with several cardiovascular and metabolic disorders. Furthermore, the T-allele is associated with the occurrence of the splice variant Gbeta3s which has been implicated in the pathogenesis of these disorders. Here, we characterise a novel splice variant of...
Topics
- Alternative Splicing
- Base Sequence
- Cell Line
- Genetic Variation
- Heterotrimeric GTP-Binding Proteins
- Humans
- Models, Molecular
- Molecular Sequence Data
- Protein Subunits
- Transcription, Genetic