Principal component analysis for selection of optimal SNP-sets that capture intragenic genetic variation.

doi:10.1002/gepi.10292

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Article

Principal component analysis for selection of optimal SNP-sets that capture intragenic genetic variation.

Genetic epidemiology - 1 Jan 2004

Horne Benjamin D, Camp Nicola J

Abstract excerpt

Candidate gene association studies often utilize one single nucleotide polymorphism (SNP) for analysis, with an initial report typically not being replicated by subsequent studies. The failure to replicate may result from incomplete or poor identification of disease-related variants or haplotypes, possibly due to naive SNP selection. A method for identification of linkage disequilibrium (LD) groups and selection...

Topics

Adult
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Haplotypes
Humans
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Principal Component Analysis

Source

Open in PubMed

Identifiers

PMID: 14691953
DOI: 10.1002/gepi.10292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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