Article
Finding haplotype tagging SNPs by use of principal components analysis.
American journal of human genetics - 1 Nov 2004
Lin Zhen, Altman Russ B
Abstract excerpt
The immense volume and rapid growth of human genomic data, especially single nucleotide polymorphisms (SNPs), present special challenges for both biomedical researchers and automatic algorithms. One such challenge is to select an optimal subset of SNPs, commonly referred as "haplotype tagging SNPs" (htSNPs), to capture most of the haplotype diversity of each haplotype block or gene-specific region. This...
Topics
- Chromosome Mapping
- Evaluation Studies as Topic
- Genomics
- Genotype
- Haplotypes
- Humans
- Polymorphism, Single Nucleotide
- Principal Component Analysis