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Article

A principal component approach to improve association testing with polygenic risk scores.

Genetic epidemiology - 1 Oct 2020

Coombes Brandon J, Ploner Alexander, Bergen Sarah E, Biernacka Joanna M

Abstract excerpt

Polygenic risk scores (PRSs) have become an increasingly popular approach for demonstrating polygenic influences on complex traits and for establishing common polygenic signals between different traits. PRSs are typically constructed using pruning and thresholding (P+T), but the best choice of parameters is uncertain; thus multiple settings are used and the best is chosen. Optimization can lead to inflated Type I...

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Identifiers

PMID: 32691445
DOI: 10.1002/gepi.22339
PMCID: PMC7722089

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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