Article
Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 1996
Tilley W D, Buchanan G, Hickey T E, Bentel J M
Abstract excerpt
Progression to androgen-independent growth of human prostate cancers may be mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date, mutations in the AR gene have largely been identified in hormone refractory tumors. In this study, single-strand conf...
Topics
- Androgens
- DNA
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Immunohistochemistry
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Prostatic Hyperplasia
- Prostatic Neoplasms