Article
Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 1996
Tilley W D, Buchanan G, Hickey T E, Bentel J M
Abstract excerpt
Progression to androgen-independent growth of human prostate cancers may be mediated by alterations in the structure and/or expression of the androgen receptor (AR) gene. To date, mutations in the AR gene have largely been identified in hormone refractory tumors. In this study, single-strand conformational polymorphism analysis and DNA sequencing of the entire AR gene coding region was performed on 25 primary...
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