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Article

Androgen receptor mutations for precision medicine in prostate cancer.

Endocrine-related cancer - 1 Oct 2022

Shiota Masaki, Akamatsu Shusuke, Tsukahara Shigehiro, Nagakawa Shohei, Matsumoto Takashi, Eto Masatoshi

Abstract excerpt

Hormonal therapies including androgen deprivation therapy and androgen receptor (AR) pathway inhibitors such as abiraterone and enzalutamide have been widely used to treat advanced prostate cancer. However, treatment resistance emerges after hormonal manipulation in most prostate cancers, and it is attributable to a number of mechanisms, including AR amplification and overexpression, AR mutations, the expression...

Topics

Androgen Antagonists
Androgen Receptor Antagonists
Androgens
Drug Resistance, Neoplasm
Humans
Male
Mutation
Nitriles
Precision Medicine
Prostatic Neoplasms, Castration-Resistant
Receptors, Androgen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35900853
DOI: 10.1530/ERC-22-0140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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